Roles of Oncogenic Fusions in Sarcoma Pathogenesis

Topic description

Subject of the thesis: Biochemical and Functional Characterization of Sarcoma Oncogenic Fusions and their interacting partners: implications for chromatin-associated processes and Cancer.

Our research embarks on a new program to characterize key sarcoma oncogenic fusions and their interactomes. These fusions, often pivotal in sarcoma development, provide an opportunity to understand the deregulated biochemical pathways in cancer. Our focus lies in the biochemical and functional characterization of these oncogenic fusions, particularly in respect to their roles in chromatin-associated processes. We aim to map out their influence on gene expression and downstream cellular processes of relevance to sarcoma development and treatment. For interested students, the project offers an invaluable opportunity to learn about proteomics, genomics, advanced molecular biology techniques and translational cancer research.

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